Van Dijk has been subject of plenty of interest throughout the summer transfer window, with Liverpool keen on the Dutchman.
He handed in a transfer request on Monday in an attempt to force through a move, but Southampton maintain he is not for sale.
Chelsea have also been linked with Van Dijk's signature maglie calcio - http://hipp-avas.com/spqr/index.php?topic=147425.0Barcelona%20trøje but Mellor reckons Liverpool are in pole position and Saints will end up selling another of their star men.
“He's a top centre-half, top centre-half,” Mellor said on Sky Sports News of Van Dijk.
“Obviously finished the season injured at Southampton. He has made his intentions clear, he doesn't want to be there any longer.
“The thing for Southampton is, they’ve always sold their best players.
“They’ve sold a number to Liverpool, obviously sold one to Manchester United as well.
“He's seen that and for his ambitions he wants to be playing back in Europe, back in the Champions League.
'I think maglie calcio - https://www.grumpyriderfans.com/member.php?action=profile&uid=15036fotba...
you’re looking at it and thinking you would be surprised if he didn't leave Southampton.
“Liverpool are looking the most likely and from a Liverpool point of view I think it would be a great signing for Liverpool.
“That's looking more likely but in football you never know until it happens.”
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